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Indeed, we observed that loss of TMEM55B or TBC1D9B in KO cells boosted ARL8B-eGFP recruitment to lysosomes marked by LAMP2 (Fig

This results in first-pass hepatic metabolism, which can significantly reduce bioavailability of peptides susceptible to liver enzymes

5 (download XLSX Statistical source data for Fig

Acknowledgements The technicians Fatih and Muhammet ahin (BSN Health) provided support with patch-clamp and plate reader investigations, for which the authors are grateful

Synthetic peptides matching these sequences displayed a dose-dependent increase in DPP-IV inhibition with IC 50 values between 78 and 116 m