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They also oxidize DNA, especially adenine and guanine (8-oxo-A and 8-oxo-G)
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however, these findings need to be further validated in randomised controlled trials, lead study author Markku Lhteenvuo, MD, PhD, of the University of Eastern Finland and the Niuvanniemi Hospital, in a statement
Importantly, a meta-analysis of 14 clinical trials evaluating gastrointestinal adverse effects of GLP-1RAs found that long-acting agents had lower rates of nausea and vomiting than short-acting formulations
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