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Izzo et al
Dig Dis Sci 58 , 26462652 (2013)
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This step, in turn, constitutes a rate-limiting factor for DNA synthesis ( 2.2 Methionine and mTOR pathway The mTOR serves as a central molecular hub that positively governs anabolic processes while simultaneously exerting negative regulation on certain catabolic pathways (Xie and Proud, 2013)
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