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By clearing leaked mtDNA, this lysosome-dependent pathway restrains cGAS-STING inflammatory signaling amplification triggered by mitochondrial damage, whereas failure to clear leaked mtDNA can sustain inflammatory signaling (67,123)
The treatment group lost approximately 2.0-2.8 kg more fat mass than placebo over the 12-week period
Data were analyzed using GraphPad Prism (version 9.5.1) and are plotted as the mean s.d
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