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The FLOW trial (N=3,533), published in the New England Journal of Medicine in 2024, showed that semaglutide 1.0 mg reduced the composite kidney endpoint by 24% in patients with type 2 diabetes and chronic kidney disease compared to placebo [8], but the trial population was closely monitored

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Given the exploratory nature of these analyses, no adjustment was made for multiple hypothesis testing

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These drugs work by mimicking the action of the naturally occurring hormone GLP-1, which is released from the gut after eating