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The proportion of adults who experienced worsened diabetic retinopathy during the trial was also similar between the two drugs

It is also not recommended for managing Type 1 diabetes or diabetic ketoacidosis, where alternative treatments are more appropriate

The retatrutide design counters this with the simultaneous GLP-1 component, whose insulinotropic and glucose-suppressive actions offset the glucagon-driven hepatic output

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Detailed statistics are in Supplementary Table 1 and chemical structures are in Supplementary Fig