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You want to avoid flooding your system to the point of diminishing returns
Metabolic acidosis risk : Topiramate can cause metabolic acidosis (elevated blood acidity) due to its carbonic anhydrase inhibitory effects
In contrast, after the addition of SB431542, a TGF signalling inhibitor, to the high-glucose medium, -SMA expression in PSCs decreased to a nearly undetectable level
Furthermore, since the instability of Ala 2 is caused by degradation of DPP-4, Ala 2 may not need to be changed if the peptide is fused with albumin or Fc domain (discussed later) for long-term activity, which creates a steric hindrance to prevent the enzyme from getting close
Obesity (Silver Spring) 19 , 110120 (2011)
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