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The public comment period closes July 30, 2026, and the rule only takes effect once the agency finalizes it

The strength of the signal was also found to differ markedly between formulations

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Patients experiencing persistent symptoms beyond 8-12 weeks of stable dosing may benefit from additional evaluation or treatment modifications

For individuals who do not respond to GLP-1, this tailored, phenotype-driven methodology within a stepped-care framework guarantees more precise and efficacious interventions, affirming the early use of medication as a scientifically substantiated and personalised strategy rather than a mere pragmatic option