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The honest summary is that topical GHK-Cu has a favorable tolerability profile for most users, but individual responses vary and rigorous large randomized trials specifically powered to detect rare harms are lacking

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Wound Healing and Tissue Remodeling Originally studied for wound healing, GHK-Cu enhances: Angiogenesis (formation of new blood vessels) Fibroblast migration and activity Tissue remodeling These effects translate into faster recovery and improved skin quality, optimizing results after procedures such as microneedling or laser treatments

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Related upstream secretagogues studied in this space include Tesamorelin and Sermorelin