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GLP-1 and GIP medications have reshaped how people think about appetite and reward, and drinking is a natural place for that curiosity to land

Differences in participant characteristics, dose-escalation schedules, adverse-event definitions, and study duration can significantly affect reported rates

Pancreatitis appeared in early animal studies, triggering concerns about long-term pancreatic safety

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This shows that natural homocysteine levels are a U-shaped curve in regard to all-cause mortality, but if there is an external reason for low homocysteine, such as excess NAC or B6, there is no statistically significant negative effect.[ref] Which brings us to the role of the gut microbiome in both low or high homocysteine