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This phenotype is characterized by a high expression of antioxidant genes, including heme oxygenase-1 (HO-1) (41), and exhibits a distinctive iron-handling profile featuring increased iron storage alongside potentially compromised iron export, leading to intracellular iron retention (42)

H., Asara, J

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This gradual effect can be easier to tolerate for patients who experience strong nausea or digestive sensitivity on weekly agents

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