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Numbers-needed-to-treat over 5 years were ~ 56 for one MACE and ~ 38 for preventing a renal eventfigures comparable to SGLT2 inhibitors
They aimed to assess the incidence of knee surgery after enrollment, along with parameters of pain and disease progression as assessed by medial femorotibial joint cartilage thickness
Santa, P
Christina Nguyen put it plainly: if Foundayo is competitive on price with oral Wegovy, "most likely everyone will go with the orforglipron." Novo pushed back on that framing
Following the successes of GLP-1 RAs, manufacturers have worked to produce similar outcomes with newer agents that affect the incretin pathways including not only GLP1 receptors but also GIP and glucagon receptors
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