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In March 2026, Roche reported that the Phase 2 ZUPREME-1 trial produced mean body-weight reductions of up to 10.7% at week 42 versus 1.7% with placebo under the reported analysis

The freeze-thaw cycle can damage molecular structure and reduce effectiveness

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The majority of findings rely on in vitro experiments and animal models, which limits the ability to generalize results beyond controlled research environments

GHK-Cu has been shown to reduce markers of inflammation and oxidative stress in both cell culture and animal models