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Studies suggest that metabolism can decrease by as much as 15% to 25% below the predicted rate, even with the medication actively working fully

Add-on value of tirzepatide versus semaglutide [PMID: 35468323] Laboratory literature summary: Add-on value of tirzepatide versus semaglutide

It is essential to consult and maintain open communication with your healthcare provider before starting any weight loss medications

It is commonly chosen by clients who have plateaued with traditional weight-loss methods and want a science-backed, metabolic approach to improving body composition

This is thought to explain its greater efficacy compared to semaglutide alone