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Pathway enrichment was evaluated against the Molecular Signatures Database, specifically using the Hallmark gene sets (h.all.v2023.2.Hs.symbols.gmt), to identify broad biological states and the C2 Reactome curated gene sets to identify high-resolution mechanistic and execution pathways
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Pax6-dependent cortical glutamatergic neuronal differentiation regulates autism-like behavior in prenatally valproic acid-exposed rat offspring
Achieving these outcomes with a second obesity medication may indicate a broader efficacy trend for pairing these 2 classes of medications. A team of investigators from the Division of Endocrinology at Mayo Clinic conducted a real-world study to determine if concurrent menopause hormone therapy enhances the effectiveness of tirzepatide for weight loss in postmenopausal women
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