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By binding to copper at the active site of tyrosinase and interfering with melanin synthesis intermediates, glutathione reduces overall melanin formation. As a powerful antioxidant, glutathione also reduces free radicalinduced oxidative stress, which is one of the triggers for increased tyrosinase activity and melanin production

Rep 77 , 14911513 (2025)

As oxidative stress increases, glutathione is used as an antioxidant, and active GSH gets depleted

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However, using glutathione skin brightening/whitening pills from reputable companies is crucial to maintain the benefits