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A compound affecting so many biological pathways could easily have subtler harms that small trials (or enthusiastic investigators) might miss

[8] A meta-analysis including 13 cardiovascular outcome trials found that SGLT-2 inhibitors reduce the risk for three-point major adverse cardiovascular events (MACE), especially in subjects with an estimated glomerular filtration rate (eGFR) below 60 ml/min, whereas GLP-1 receptor agonists were more beneficial in persons with higher eGFR

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Long-term Fat Reduction Performance A 5-year follow-up cohort from Mount Sinai Medical Center in Los Angeles provides long-term volume change records for both drugs

J Hepatol 79(6):15421556 Makri E, Goulas A, Polyzos SA (2021) Epidemiology, Pathogenesis, diagnosis and emerging treatment of nonalcoholic fatty liver disease