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and 4hypertonic flexor and extensor muscles, clonus and hyperreflexia, the latter including a positive curling reaction

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GLP-1 agonists like semaglutide and tirzepatide slow gastric emptying by 30-40% as part of their mechanism of action (Nauck et al., Diabetologia, 2011)

In reality, starting high increases side effects, makes it impossible to identify your true minimum effective dose, and may actually reduce effectiveness if receptor downregulation occurs

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