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It reduces oxidative stress that accelerates wrinkles and pigmentation
, DSIP
Since vicinal water has a larger volume than ordinary water (analogous to the expansion when ice is formed, though the volume increase in cell water is slightly less, about 4%, than in ice, which is 11% more voluminous than liquid water), compression under high pressure converts vicinal cell water to the state that occurs in the excited cell, the way ice melts under pressure
This review synthesizes evidence from about 120 preclinical/clinical studies sourced from PubMed, Scopus, and Web of Science using keywords (e.g., nutraceutical-drug interactions, bioavailability, CYP/P-gp modulation), prioritizing recent advances (20152024) alongside seminal works to contextualize mechanisms
5 , e508e522 (2023)
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