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Patients may be stuck in a chronic state of cyclical inflammation leading to tissue degeneration, refractory symptoms, and disability

10.1016/j.bcp.2004.05.046 29 DemaegdtH.LenaertsP.-J.SwalesJ.De BackerJ.-P.LaeremansH.LeM

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They have discovered that polyphenols may exhibit the ability to scavenge free radicals through (1) direct reaction with reactive oxygen species (ROS), (2) enhanced dismutation of free radicals to compounds with much lower reactivity, (3) inhibition of catalase enzyme activity, (4) increased activity of antioxidant enzymes such as SOD, (5) chelation with pro-oxidative metals like iron and copper, and (6) increasing the effectiveness of other small antioxidants like tocopherols and ascorbic acid [208, 209]

Recall, estrogen levels begin to decline around 30 years of age in women [9, 10], so the clinical trials selected for presentation include participants who were aged 30 to over 65 years