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This interesting finding, occurring without weight loss, is consistent with preclinical and clinical studies showing weight-independent effects of GLP-1R agonism on liver steatosis 51,52,53
Lipid metabolism PUFAs are catalyzed by ACSL4 and LPCAT3 to form PUFA-PLs, which are further oxidized by ALOX to produce PUFA-OOH, ultimately leading to the formation of LPO that induce ferroptosis
doi: 10.3389/fbioe.2021.677576 Received 07 March 2021 Accepted 12 April 2021 Published 29 April 2021 Volume 9 - 2021 Edited by Zhen Li, AO Research Institute, Switzerland Reviewed by Guangli Suo, Suzhou Institute of Nano-tech and Nano-bionics (CAS), China
Some Paloma patients are also losing weight with the help of treatment with GLP-1 medications
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