However, despite affinity, albeit lower, of tirzepatide for the GLP-1 receptor, tirzepatide had no effect on body weight, food intake, fasting insulin, endogenous glucose production and insulin-stimulated glucose uptake in skeletal muscle and subcutaneous white adipose tissue of GLP-1 receptor knockout mice [89]
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Patients taking semaglutide can expect to lose on average 21% of their starting weight over 72 weeks, while those taking liraglutide can expect to lose around 8%
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In contrast, CME_d maintains stability around 1 , indicating better overall stability