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The medications are most effective when combined with dietary modification, physical activity, and behavioural support
All evaluated GLP-1 RAs were not associated with significant increased risk of cholelithiasis, in the following order: tirzepatide (RR 1.3566 [95% CI 0.2354, 7.8184
Data from the STEP 4 trial demonstrated that discontinuation of semaglutide typically results in return of appetite and substantial weight regain, indicating that for many individuals, ongoing treatment may be necessary to maintain benefits
This can make it easier to stick to a reduced-calorie diet and practice healthier eating habits
doi: 10.1021/acsnano.4c10742 284 FengQZhangXZhaoXLiuJWangQYaoYet al
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