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Common gastrointestinal side effects include: Nausea and vomiting : Usually most pronounced during initial treatment and dose escalation, often improving over 48 weeks Diarrhoea or constipation : Can affect hydration and nutritional status Abdominal discomfort : Typically mild and transient Patients can manage mild gastrointestinal symptoms by eating smaller, more frequent meals, avoiding high-fat foods, staying well-hydrated, and taking the medication as directed

Each professional brings a unique perspective and expertise, contributing to a comprehensive, patient-centred care model in which interdisciplinary collaboration is essential to address the diverse clinical, metabolic, and psychosocial challenges posed by obesity [16, 145]

9 The semaglutide group exhibited significant improvements in symptoms and physical limitations, assessed using the Kansas City Cardiomyopathy Questionnaire Clinical Summary Score (KCCQ-CSS), with the change in KCCQ-CSS being the primary trial endpoint

The literature tells us to use it continuously Its been our experience that if the patients dont take a break, they get accommodated to it and it stops working, especially for weight loss

[1] [2] These sites have been selected to ensure consistent drug absorption and patient safety