The accumulated data support a multifactorial explanation: cardiometabolic burden is reduced, while the rapid separation of MACE event curves in placebo-controlled trials within months and before substantial weight loss together with imaging evidence for plaque stabilization and reduced coronary inflammation, plausibly support a contribution from direct vascular anti-inflammatory and endothelial mechanisms [9], [24], [25]
The Three Habits That Make GLP-1 Therapy Work Long-Term Medication creates metabolic space
Some people with high baseline body weight or metabolic sensitivity see meaningful results even at low doses
They do not predict response to retatrutide, tirzepatide, semaglutide, or any specific medication, but they can help map the baseline metabolic terrain a healthcare provider is working within
The timing, sources, and distribution of protein consumed throughout the day may all also have effects on SMM retention or accrual as summarized elsewhere