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In Phase 2 trials, this triple mechanism produced weight loss of up to 24.2% of body weight at 48 weeks, surpassing results seen with semaglutide and tirzepatide in comparable timeframes
A physician can prescribe them or refer patients to a specialist for further evaluation
The glucose-dependent mechanism means that when blood sugar levels are normal, insulin secretion is not excessively stimulated, providing a safer metabolic profile than some older diabetes treatments
These GLP-1 analogs affect glucose-dependent insulinotropic polypeptide receptors and glucagon receptors, in addition to GLP-1R and are expected to exhibit stronger anti-obesity effects than that of semaglutide [21, 22]
If appropriately marketed, off-patent versions could open the door to millions of new patients who were previously priced out
