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26 However, in a 5-year follow-up of a subset of these patients without hypertension at the start of the study, there was no association between the development of hypertension and sleep apnea after accounting for body mass index (BMI), suggesting this association may instead be caused by obesity
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In addition, tumour tissue exposure may not directly correlate with plasma concentration, and intracellular accumulation within malignant cells remains incompletely characterized for many compounds
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