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This article was originally published on 08.05.2025 and updated on 17.02.2026
The American College of Physicians recommends setting realistic expectations: clinically meaningful weight loss is defined as 5% or greater reduction in baseline body weight
The most concrete human evidence is concentrated in topical skin and specific wound-study contexts [2], [3], [8]
The clinical support model is medium-tier with standard provider consultations and progress monitoring
But now can tolerate more variety
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