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APPROVED Analyst ID: ZH-807 RPh: A-46343 2026-02-20 Reviewer ID: QR-133 RPh: A-84996 2026-02-20 QA Director ID: QA-687 Senior Engineer Cert

However, in ob/ob mice, AOD9604 and hGH significantly reduced epididymal fat mass by 28% and 40%, respectively

The 50100mg daily dose range was derived from rodent models where 10mg/kg bodyweight produced measurable NNMT suppression without toxicity across 12-week administration periods