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Covalent/irreversible inhibitors target the redox/catalytic apparatus of TGR with almost no recognition elements that give affinity and selectivity for TGR over off-targets and the cellular redox apparatus resulting in undesirable cross-reactions and low specificity in vivo 25
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Yes, but it requires a cold chain
Food, microbiota and bile acids have been discussed as possible inducers of low-grade inflammation and impaired permeability in IBS
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