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The effect on truly "stubborn" subcutaneous fat (which is resistant due to higher alpha-2 adrenergic receptor density) is unclear
Clinical studies tested doses ranging from 250mcg to 1mg daily, with 300mcg showing effective fat reduction at the lowest side effect profile
Body Composition Changes: More significant changes, such as a reduction in body fat or noticeable weight loss, typically occur over a period of 48 weeks
Once the body adapts to running on mobilized fat stores rather than relying solely on dietary glucose, energy levels often stabilize at or above baseline
In these clinical cases, injections may be given three times a week for several weeks until symptoms begin to subside
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