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For example, in fluid resuscitation, pediatric fluid requirements must be tailored to body weight, and the recommended infusion rates differ physiologically from those for adults

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However, there is insufficient evidence to recommend it for those with diabetes or advanced fibrosis

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In animals, specifically DR in its various forms (CR/IF/STS, KD, protein restriction) has shown a potential for simultaneously targeting many of the pathways associated with insulin and IGF signaling, usually with no serious, or with even beneficial side effects such as a differential stress response between normal and tumor tissue