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doi:10.1016/j.hermed.2020.100404 [16] Shahzad M, Yang X, Raza Asim MB, et al

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In addition to High-dose intravenous acetylcholine severe vasodilation and a profound drop in blood pressure, the high concentration of acetylcholine directly stimulates M2 muscarinic receptors in the sinoatrial (SA) node of the heart (Brown & Eccles, 1934)