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Most AEs were mild and GI-related, consistent with GLP-1RAs
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Primary Clinical Trials: NCT05881486 (TRIUMPH-1): A Study of Retatrutide (LY3437943) in Participants With Overweight or Obesity
The molecular design incorporates several structural features that are understood to enhance its pharmacological properties, based on published preclinical data and trial documentation: Fatty acid side chain attachment : Retatrutide is reported to be conjugated to a fatty acid chain via a linker, a modification that enables the molecule to bind to albumin (a protein in the bloodstream)
