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Our findings indicate that FOXO4-DRI promotes apoptosis in senescent cells by disrupting the FOXO4-P53 interaction, thereby releasing and phosphorylating P53, which then translocates to the cytoplasm
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Gastric bypass increases circulating bile acids and activates hepatic farnesoid X receptor (FXR) but requires intact peroxisome proliferator activator receptor alpha (PPAR) signaling to significantly reduce liver fat content
Competing interests D.G
It aids in the breakdown of toxic substances and plays a central role in protein synthesis, bile production, and the metabolism of fats and glucose
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