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Since the development of the first GLP-1 medication, Byetta, by Amylin Pharmaceuticals in 2005 and its commercialization by AstraZeneca, these drugs have been widely used for managing type 2 diabetes
Rybelsus is best taken on an empty stomach when you first wake up, at least 30 minutes before food, and with a small amount of water (no more than 4 oz)
In all three cases, the final levels increased, except in the case of Glu/Crea which was not significant
More than 21 days at room temperature (for FDA-approved pens and vials)
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![Mechanism of action of GLP-1 [25]](https://www.researchgate.net/profile/Asfandyar-Sheikh/publication/256289222/figure/fig1/AS:614177232142337@1523442671231/Mechanism-of-action-of-GLP-1-25.png)
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