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Clark, A
doi:10.1152/ajpendo.2001.281.2.E197 Tipton KD, Gurkin BE, Matin S, Wolfe RR
they are prepared per individual prescription and are not reviewed by FDA for safety, effectiveness, or quality FDA regulatory context as of June 2026: The semaglutide shortage was declared resolved in February 2025
Regulatory environment (external): Active uncertainty - FDA's April 2026 proposal to restrict 503B compounding remains open for public comment through June 29, 2026
One untested hypothesis is that injecting into abdominal fat - which sits in close proximity to the enteric nervous system (the second brain in your gut) - may allow the medication to leak or transport locally to gut receptors before it even enters your general circulation
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