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Model and physiological GSSR substrates are, for example, l-cysteine-glutathione disulfide (GSSCys) 9,10,11,12,13,14,15 , coenzyme A-glutathione disulfide 3,16 , as well as S -glutathionylated serum albumin 9,11,17,18,19,20 , sirtuin 21 , sulfiredoxin 22 , and peroxiredoxins 23,24,25,26,27,28,29

Downstream transcription factors showed dramatic upregulation: c-Fos by 4.99-fold, c-Jun by 7.05-fold, and Egr-1 by 3.70-fold

The solution still looks clear

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