Personal physiology and underlying health status influence how someone may respond to such compounds.
(PDF) Harnett, N.G., Finegold, K.E., Lebois, L.A.M., van Rooij, S.J.H., Ely, T.D., Murty, V.P., Jovanovic, T., Bruce, S.E., House, S.L., Beaudoin, F.L., An, X., Zeng, D., Neylan, T.C., Clifford, G.D., Linnstaedt, S.D., Germine, L.T., Bollen, K.E., Rauch, S.L., Haran, J.P., Storrow, A.B., Lewandowski, C., Musey, P.I., Hendry, P.L., Sheikh, S., Jones, C.W., Punches, B.E., Kurz, M.C., Swor, R.A., Hudak, L.A., Pascual, J.L., Seamon, M.J., Harris, E., Chang, A.M., Pearson, C., Peak, D.A., Domeier, R.M., Rathlev, N.K., ONeil, B.J., Sergot, P., Sanchez, L.D., Miller, M.W., Pietrzak, R.H., Joormann, J., Barch, D.M., Pizzagalli, D.A., Sheridan
In addition to being used for clinical diagnosis (diagnostic biomarkers), determination of clinical trial eligibility (screening biomarkers), and guiding treatment decisions (prognostic biomarkers), biomarkers can also be used to demonstrate target engagement and to assess the response to an intervention (response biomarkers) (Cummings, 2019
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