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Giving -X/-X to all creatures gets around indestructible, protection, and damage prevention

This first flavor of chaotic-commander warps game mechanics into rule-bending pretzels

Giant Growth is an instant card that can be played after attackers and blockers are declared, bolstering a target creature's power and toughness by three

Are they treated as activating at separate timings

If you choose both modes, and the target of the first mode is an illegal target at the time Artistic Refusal tries to resolve (probably because that spell has been countered by something else), Artistic Refusal won't resolve and none of its effects will happen